Performance evaluation of fluorescence tomography in a Siemens Inveon multimodality scanner
2014
A tri-modal (PET/CT/Optical) small animal tomographic imaging system was developed by
integrating our advanced non-contact intensified CCD (ICCD) frequency-domain fluorescence
imaging components into a Siemens Inveon scanner. We performed a performance evaluation
of the developed imaging system by using the developed regularization-free high-order
radiative-transfer-based reconstruction algorithm and custom solid phantoms. Our results show
that frequency-domain photon migration (FDPM) fluorescence tomography can achieve better
tomographic images with less artifacts and more precise fluorescent source localization
compared to the continuous-wave counterpart. The developed multimodal tomographic imaging
system provides a powerful tool for translational biomedical research.
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