PD03-06 IMPACT OF C-REACTIVE PROTEIN-ALBUMIN RATIO (CAR) ON PREDICTION OF PROGNOSIS IN PATIENTS WITH METASTATIC RENAL CELL CARCINOMA

INTRODUCTION AND OBJECTIVES:To evaluate the impact of pretreatment C-reactive protein/albumin ratio (CAR) on prognosis and the effect of adding CAR in the International Metastatic Renal Cell Carcinoma Database Consortium (IMDC) model for prognosis discrimination in patients with metastatic renal cell carcinoma (mRCC).METHODS:A retrospective study was performed in 176 patients with mRCC who received first-line tyrosine kinase inhibitors. Prognostic value of CAR was tested using the Kaplan–Meier method and Cox proportional regression models. The effect of adding CAR in the IMDC model (IMDC-CAR) for overall survival (OS) discrimination was evaluated using receiver operator characteristic (ROC) curves, integrated discrimination improvement (IDI), and net reclassification improvement (NRI).RESULTS:CAR was significantly different among the IMDC favorable-, intermediate-, and poor-risk groups. The optimal cutoff value of CAR for OS was defined as 0.05 by ROC analysis, and patients were stratified into two groups...