PL-48: Gastric electrical stimulation with Tantalus® improves glycemic control in overweight subjects with type 2 diabetes

2 men) preand 1 year post-bariatric surgery (vertical banded gastroplasty 8, gastric bypass 5, duodenal switch 3). Patients on anti-hypertensive or cholesterol lowering drugs were excluded. We measured leptin, lactate, pyruvate, 2,3-diphosphoglycerate (2,3-DPG), pH, and the OTR by dynamic oximetry. OTR methodology initiated in our laboratory and consists of the evaluation of the rate of hemoglobin desaturation in vitro as the blood O2 saturation goes from 100% to 60%. The endpoint of anaerobic glycolysis is lactate, of aerobic it is pyruvate. The lactate-pyruvate ratio decreases with increasing aerobic glycolysis. 2,3-DPG, an intermediate in glycolysis, modulates the hemoglobin/oxygen dissociation curve; when 2,3-DPG decreases, the curve shifts to the left, reducing the OTR. Statistical analysis by t-test. Results: The 1 year average %EBWL was 55.6% (37.7 kg). All calculated indicators decreased: leptin -34.8% (p .04), lactate/ pyruvate ratio -16% (p .12), 2,3-DPG -38.8% (p .001), and pH -.7% (p .05). The OTR decreased -18.3% (p .03 at 5 minutes. Conclusion: Bariatric surgery is associated with changes in metabolic parameter indicative of a shift from anaerobic to more energy efficient aerobic metabolism.