Loss of CXCR3 expression on memory B cells in individuals with long-standing type 1 diabetes
2018
Aims/hypothesis
Islet-specific autoantibodies can predict the development of type 1 diabetes. However, it remains unclear if B cells, per se, contribute to the causal pancreatic immunopathology. We aimed to identify phenotypic signatures of disease progression among naive and memory B cell subsets in the peripheral blood of individuals with type 1 diabetes.
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