SYNTHESIS OF POLYPEPTIDE MODELS OF COLLAGEN

The synthesis of several sequential oligomer models of collagen is reported. Polytripeptides H(-Pro-Gly-Leu-)n OH, H(-Pro-Gly-Phe-)n OH, H(-Pro-Sar-Gly-)n OH, H-(-Sar-Pro-Gly-)n-OH, H(-Pro-Gly-Val-)n OH and H(-Gly-Val-Pro-)n OH were synthesized by the active ester method. Preliminary fractionation and mol.wt. determination showed typical gaussian distributions. Good yields were obtained in the mol.wt. range of 4,000–6,000, except in the case of H(-Pro-Sar-Gly-)n OH which yielded molecular weights over 20,000.