TOP2A expression predicts responsiveness to carfilzomib in myeloma and informs novel combinatorial strategies for enhanced proteasome inhibitor cell killing.

Antonia Reale,Tiffany Khong,Sridurga Mithraprabhu,Ioanna Savvidou,Jay Hocking,Krystal Bergin,Malarmathy Ramachandran,Maoshan Chen,F. Dammacco,Roberto Ria,Francesco Silvestris,Angelo Vacca,John V. Reynolds,Andrew Spencer

TOP2A expression predicts responsiveness to carfilzomib in myeloma and informs novel combinatorial strategies for enhanced proteasome inhibitor cell killing.

2020

Antonia Reale
Tiffany Khong
Sridurga Mithraprabhu
Ioanna Savvidou
Jay Hocking
Krystal Bergin
Malarmathy Ramachandran
Maoshan Chen
F. Dammacco
Roberto Ria
Francesco Silvestris
Angelo Vacca
John V. Reynolds
Andrew Spencer

Microarray was utilized to determine if a genetic signature associated with resistance to carfilzomib (CFZ) could be identified. Twelve human myeloma (MM) cell lines (HMCLs) were treated with CFZ a...

Keywords:

cell killing
Proteasome inhibitor
Microarray
Cancer research
genetic signature
Biology
Multiple myeloma
Cell culture
Carfilzomib
Proteasome Inhibition

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