Three-dimensional analysis of choroidal vessels in eyes with Vogt-Koyanagi-Harada disease before and after treatment.

Abstract Objective To investigate a 3-dimensional analysis of choroidal vessels using binarization of ultrawide-field indocyanine green angiography (UWFICGA) images and swept-source optical coherence tomography (SS-OCT) images before and after treatment in eyes with Vogt-Koyanagi-Harada (VKH) disease. Methods Seven eyes of 7 patients (2 men and 5 women; mean age, 48.3 years) with VKH disease and 8 control eyes of 8 patients (4 men and 4 women; mean age, 47.6 years) who visited from August 1, 2015, through July 31, 2017, were enrolled. UWF fluorescein angiography images were subtracted from UWFICGA images in all patients to evaluate the choroidal vessel densities. A vertical analysis of the choroid also was performed in the same way with SS-OCT images. Results At the acute stage of VKH disease, the mean choroidal vascular densities in both posterior and mid-peripheral areas were significantly (p Conclusions Current results suggest that diffuse cellular infiltration into the choroidal stroma might compress choroidal vessels and the change would resolve after treatment.