Do allergic dogs exhibit features of a severe steroid-resistant allergic airway phenotype?

Background Most asthmatic patients respond favorably to corticosteroid therapy, however, a subpopulation of patients (5-10%) display persistent immune activation and airway inflammation, despite high doses of oral/inhaled corticosteroids. The development of more predictive animal models that incorporate the severe steroid-resistant phenotype are needed to better define translational biomarkers and therapeutic targets for this patient population.