HEPATOPROTECTIVE ACTIVITY OF MIMOSA PUDICA LINN. IN CARBON TETRACHLORIDE INDUCED HEPATOTOXICITY IN RATS

Mimosa Pudica Linn. is a commonly used herbal drug against many diseases. The hepatoprotective activity of hydroalcoholi c extract of dried powder of whole plant of Mimosa Pudica Linn. was investigated in hepatotoxicit y rat model. Hepatotoxicity was induced in Wistar rat s by intraperitoneal injection of carbon tetrachloride. Different doses were tested to decide the dose related hepatoprotective efficacy of Mimosa pudica Linn. (200 mg/kg, 400 mg/kg, 800 mg/kg body weight/day po for two weeks). The Hepatoprotective effect of these extracts was evaluated by liver function biochemical parameters (i. e. total and direct bilirubin, cholesterol, serum glutamateoxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT) and alkaline phosphatase activities) and histopathological examination of liver. In extract-treated animals, the toxicity effect of carbon tetrachloride was controlled significantly by restoration of the levels of serum bilirubin, cholesterol and enzymes (SGOT, SGPT) as compared to the normal and standard drug silymarin- treated groups. Histology of liver sections of the animals treated with the extracts showed the hepatic cell regeneration. Therefore, the results of present study support the hepatoprotective effect of Mimosa Pudica Linn.