Triagem de hemoglobinopatias e avaliação da degeneração oxidativa da hemoglobina em trabalhadores portadores do traço falciforme (HbAS), expostos a riscos ocupacionais Screening of abnormal hemoglobin and the evaluation of oxidative degeneration of hemoglobin among workers with the sickle cell trait (HbAS), exposed to occupational hazards

Abstract Hemoglobinopathies are frequent hereditary diseases in Brazilianpopulation and have been a public health problem. This study reportsthe screening of abnormal hemoglobin among Fiocruz`s employees,as well as the impact of exposure to some factors such as, chemicalsubstances, radiation, excessive cold or heat in sickle cell traitcarriers. This impact has been analyzed by measuringmethehemoglobin level and the presence of Heinz bodies. Thesamples were obtained from 2190 (4,7%) individuals presentedabnormal hemoglobin. Hemoglobin S was found in 72,3% ofindividuals with abnormal hemoglobin constituting the mostprevalent. The results distribution were: sickle cell trait in 3,2%and associated with thalassemia in 0,2%; thalassemia in 0,7%; AChemoglobin in 0,4%; thalassemia minor in 0,3% and finally SS andD hemoglobin in 0,05%. Sickle cell trait carriers employees had a14 times higher risk of increased methehemoglobin increase levels.Rev. bras. hematol. hemoter. 2005; 27 (3):183-187.