Phamacokinetics of Rapacuronium in Infants and Children with Intravenous and Intramuscular

I] Background. A nondepolarizing muscle relaxant with an onset and offset profile similar to succinylcholine is desirable for pediatric anesthesia. The onset and offset of rapacuronium are rapid in children. In the current study, the authors determined its pharmacokinetic characteristics in children. In addition to administering rapacuronium by the usual intravenous route, the authors also gave rapacuronium intramuscularly to determine uptake characteristics and bioavailability. Methods: Forty unpremedicated patients aged 2 months to 3 yr were anesthetized with halothane, 0.82-1.0% end-tidal concentration. When anesthetic conditions were stable, rapacuronium was injected either into a peripheral vein (2 mg/kg for infants, 3 mg/kg for children) or a deltoid muscle (2.8 mg/kg for infants, 4.8 mg/kg for children). Four venous plasma samples were obtained from each subject 2-240 min after rapacuronium administration. A mixed-effects population pharmacokinetic analysis was applied to these values to determine bioavailability, absorption rate constant, and time to peak plasma concentration with intramuscular administration. Results: Plasma clearance was 4.77 ml . kg-' . min-l + 8.48 mVmin. Intramuscular bioavailability averaged 56%. Absorption from the intramuscular depot had two rate constants: 0.0491 min-' (72.4% of absorbed drug) and 0.0110 min-' (27.6% of the absorbed drug). Simulation indicated that plasma concentration peaks 4.0 and 5.0 min after intramuscular rapacuronium in infants and children, respectively, and that, at 30 min, less than 25% of the administered dose remains to be absorbed from the intramuscular depot. Conclusions: In infants and children, rapacuronium's clearance and steady state distribution volume are less than in adults. After intramuscular administration, bioavailability is 56%, and plasma rapacuronium concentrations peak within 4 or 5 min. (Key words: Intramuscular injections; mixed-effects modeling; ORG9487.) RECENT trials in adults' and children' showed that the onset of intravenous rapacuronium is rapid, approaching that of succinylcholine. In addition, recovery from a bolus dose of rapacuronium is similar to that from mivacurium, currently the nondepolarizing muscle relaxant with the shortest duration of action.3 These characteristics suggest that rapacuronium can be valuable for pediatric anesthesia. In the current study, we determined the pharmacokinetics of rapacuronium in infants and children. In addition, because a recent pilot study from the University of California, San Francisco' suggested that