Isolation and identification of a common intermediate produced by blocked mutants from β-rhodomycin and daunomycin producers

Biosynthetically blocked mutants isolated from the β-rhodomycin-producing Streptomyces violaceus A262 strain SC-7 and daunomycin-producing Streptomyces sp. D788 strain G1-1 were found to accumulate maggiemycin in their culture broths. Bioconversion tests using mutants that did not produce these antibiotics also proved that maggiemycin is a common precursor in the biosynthesis of β-rhodomycin and daunomycin.