Características clínicas de pacientes con Linfomas de Células del Manto
2021
Introduction: Mantle cell lymphoma represents less than 10% of all non-Hodgkin lymphomas. It is characterized by aggressive behavior. Objective: Describe the clinicopathological characteristics of patients diagnosed with mantle cell lymphoma. Methods: An observational retrospective study was conducted of 40 patients diagnosed with mantle cell lymphoma attending the Institute of Oncology and Radiobiology from 2008 to 2019. The variables considered were demographic characteristics of patients, disease features at diagnosis and treatment indicated. Overall survival was estimated with the Kaplan-Meier method. Results: Mean age at diagnosis was 62 years. Of the patients studied, 55.0% were female. According to Ann Arbor staging, 20% and 50% were at clinical stage III and IV, respectively. 40% presented extranodal involvement in the digestive system. 25% received rituximab-related regimens, of which 42.5% were cytarabine-based. Complete response was achieved in 77.5% of the cases after induction therapy. Overall survival was 46.3% at 5 years. Conclusions: Mantle cell lymphoma is an infrequent condition. In most cases it is diagnosed at advanced stages, with extranodal damage. High response rates are obtained with induction therapy. Key words: mantle cell lymphoma; non-Hodgkin lymphoma; immunotherapy; chemotherapy.
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