Production of Piperonal, Vanillin, and p-Anisaldehyde via Solventless Supported Iodobenzene Diacetate Oxidation of Isosafrol, Isoeugenol, and Anethol Under Microwave Irradiation

A novel experimental procedure to obtain carbonyl compounds under microwave irradiation from activated olefins and supported iodobenzene diacetate is described. By varying the reaction conditions it is possible to generate the corresponding aldehydes in reasonable-to-excellent yields and selectivities. The methodology is simple, clean, and reproducible and presents short reaction times. Using isosafrol, isoeugenol, and anethol it was possible to produce piperonal, vanillin and p-anisaldehyde, respectively.