Preparation method of everolimus and intermediate of everolimus

The invention discloses preparation method of everolimus and an intermediate of everolimus and particularly relates to a preparation method of the medicine everolimus and the intermediate of the everolimus. The preparation method comprises the following step of carrying out reaction on a compound (II) in an organic solvent to prepare a target product in the presence of a deprotection system. The preparation method disclosed by the invention is safe, low in cost, high in yield and easy to purify and industrialize. The formula is shown in the description.