Sperm maturity and treatment choice of in vitro fertilization (IVF) or intracytoplasmic sperm injection: diminished sperm HspA2 chaperone levels predict IVF failure ☆

Abstract Objective: To reexamine whether low sperm HspA2 ratios (formerly sperm CK-M ratio ) are predictive for failure to cause pregnancies by in vitro fertilization (IVF) and to explore whether there are other male or female factors that may be predictive for IVF pregnancy outcome. Design: Retrospective, cohort study. Setting: University-based IVF program. Patient(s): In 119 IVF cycles, three patient groups were studied: 25 men had a 10% sperm HspA2 ratio and no pregnancies (HS >10%NP group), and another 44 couples had a >10% sperm HspA2 ratio but did achieve pregnancies (HS >10%P group). Intervention(s): Sperm HspA2 ratio determinations within 1 year of the IVF cycles and analysis of male and female IVF cycle parameters. Main Outcome Measure(s): Sperm HspA2 ratio determinations within 1 year of the IVF cycles and analysis of male and female IVF cycle parameters. Result(s): In the three groups, male and female ages, number and maturation level of oocytes, and morphology of embryos were similar. In the HS 10% groups. The receiver operating characteristic curve in men with sperm HspA2 ratios of Conclusion(s): HspA2 ratios of