Uncommon Mature T-Cell Lymphomas
2020
Common T-cell leukemias/lymphomas frequently involving the spleen and liver include entities such as T-cell prolymphocytic leukemia, aggressive NK-cell leukemia, and hepatosplenic T-cell lymphoma. The involvement of the spleen and liver by other nodal or extranodal T-cell or NK-/T-cell lymphomas is less common and mostly as part of disseminated disease. The clinicopathologic features of these uncommon mature T-cell lymphomas in the spleen and liver, including peripheral T-cell lymphoma, NOS, adult T-cell leukemia/lymphoma, angioimmunoblastic T-cell lymphoma, ALK-positive and ALK-negative anaplastic large cell lymphoma, and extranodal NK-/T-cell lymphoma, nasal type, are discussed in this chapter. Spleen and liver biopsies are typically not obtained in these lymphomas, as diagnosis is typically made on lymph node or other primary sites of involvement.
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