Serum xylosyltransferase I activity, the new biochemical fibrosis marker, is not affected by renal insufficiency

Abstract Objectives: Serum xylosyltransferase I (XT-I) is a marker for the determination of tissue remodeling in systemic sclerosis. Here, we investigated whether renal insufficiency affects XT-I levels in blood. Methods: We measured serum XT-I activity in 236 patients with different serum creatinine levels. Results: XT-I activities in cohorts with increased creatinine levels were not significantly altered compared to controls. Conclusions: Serum XT-I activity is applicable as a fibrosis marker independent from renal function.