MDM2 309 polymorphism is associated with missed abortion

background: In this study, we assessed whether the single nucleotide polymorphism in the murine double minute 2 (MDM2) promoter (SNP309) was associated with the occurrence of missed abortion. methods: Genotyping of MDM2 SNP309 polymorphism was conducted by polymerase chain reaction-restriction fragment length polymorphism with blood and villous samples from 95 women diagnosed as having 1st trimester missed abortion. results: The MDM2 SNP309 G/G genotype was associated with a higher risk of missed abortion compared with the T/T þ T/G genotype in blood (P ¼ 0.010; odds ratio (OR): 2.164; 95% confidence interval (CI): 1.207 –3.878) and villous samples (P ¼ 0.043; OR: 2.767; 95% CI: 1.092 –7.011). conclusions: The MDM2 SNP309 G/G genotype may be a genetic risk factor for missed abortion.