P.2.028 Enhanced vulnerability to cocaine reinforcing effects in female H/Rouen mice selectively bred for depressive-like behaviour

leads to good memory performance of rats (1 h interval ORT, repeated measures ANOVA; MLA (F3,51 = 7.33; P< 0.001). This indicates that MLA could act both as a cognition enhancer and as a deficit model in this paradigm. Among other possibilities, one explanation for these findings could be that a7 nAChR antagonists promote a7 nAChR resensitisation. Since a7 nAChRs desensitise fast, by occupying a subset of a7 nAChRs with selective antagonists without intrinsic value, these receptors could have an opportunity to recover or resensitise. This hypothesis is currently investigated. In summary, while the main focus of the a7nAChR as a target for cognition enhancement lies on agonists and positive modulators, the antagonists of these receptors might prove to be a valuable tool for cognition enhancement in AD or schizophrenia.