The Effect of Diammonium Glycyrrhizinate Lipid Ligand on Alcoholic Fatty Liver

AIM:To study the therapeutic effect of Diammonium Glycyrrhizinate lipid ligand(DGLL) on alcoholic fatty liver.METHOD:Rat models of alcoholic fatty liver were induced by ig.alcohol continuously.After the models were established successfully,were provided DGLL and polyene phosphatidylcholine(PPC).Serum hepatic function indexes and lipid contents of both serum and liver tissue were measured according to the instruction of Test kits.Liver tissue was dyed with HE and histopathological changes in liver were observed under light microscope.RESULT:Rat models of alcoholic fatty liver were induced successfully after ig alcohol for 5 weeks.After treatment by DGLL and PPC for 2 weeks,the level of AST in the serum,triglycerides (TG ) and total cholesterol (TC) in liver of rats with alcohol fatty liver decreased significantly.Histopahological changes of liver were improved.Meanwhile, the level of serum TG、TC and MDA in DGLL middle dose-treated rats deceased significantly.CONCLUSION:Both DGLL and PPC improved fat metabolism in alcoholic fatty liver rats and possessed therapeutic effect on alcoholic fatty liver.