Model-based, goal-oriented, individualised drug therapy : Linkage of population modelling, new 'multiple model' dosage design, Bayesian feedback and individualised target goals

This article examines the use of population pharmacokinetic models to store experiences about drugs in patients and to apply that experience to the care of new patients. Population models are the Bayesian prior. For truly individualised therapy, it is necessary first to select a specific target goal, such as a desired serum or peripheral compartment concentration, and then to develop the dosage regimen individualised to best hit that target in that patient.