Designing of an Adipic acid bridged Zn(II) coordination polymer: Synthesis and biological study

Abstract In the structure of [Zn(ppmh)(adp)(H2O)]n [adp2−, adipate ion; ppmh, N-Pyridin-2-yl-N'-pyridin-4-ylmethylene-hydrazine], Zn(II) is bridged by dicarboxylato-O of two independent adp2− and ppmh is affixed through pyridyl-N and water coordinates to form ZnO3N tetrahedral coordination motif. The H-bonding and π—π interactions with pendant ppmh help to construct a 3-D supramolecular network. The optical band gap, 3.22 eV, is lower than that of DFT computed energy gap, 3.71 eV which may be due to not inclusion of framework strain in the calculation. The compound shows antibacterial activity [IC50, 186 ± 2.1 µg/mL (E. coli) and IC50, 190.12 ± 2.64 µg/mL (S. aureus)] and active against HepG2 (Human Liver) cancer cells [LD50, 58 µg/mL].