Action of morphine on reproduction and immunological status in mice

The course of embryogenesis is disturbed in CBA mice during prolonged administration of morphine. There is a parallel decrease in the level of antibody-synthesizing cells and a significant fall in cooperative interaction between T-and B-lymphocytes in response to injection of sheep's red blood cells. Meanwhile stimulation of bone marrow cells and specific sensitization of producers of migration inhibition factor to antigen from the brain of mice treated with morphine are observed.