Interleukin in Periodontal Health and -22 (IL-22) Gingival Gene Expression and GCF Concentration Disease
2014
IL-22 is a cytokine that is assumed to improve anti-microbial defense of epidermal and epithelial cells and the cells of gastrointestinal
and respiratory systems. With respect to absence of enough relevant articles in this regard the aim of this study
was to evaluate the correlation between IL-22 gene expression in gingival tissues as well as its concentration in GCF and
periodontal diseases. Gingival samples obtained from 60 patients of three different groups (healthy, gingivitis and chronic
periodontitis) and used for evaluation. Expression of IL-22 mRNA was measured by Real-time PCR and its concentration
in GCF was determined by ELISA. In none of the tissue samples, mRNA of IL-22 was detected; However IL-22 concentration
was significantly higher in periodontitis in comparison to other groups and in gingivitis was higher than the normal
gingiva. There was no relationship between concentration of IL-22 in GCF and the extent and severity of chronic periodontitis.
With respect to the results of this study, probable systemic production of IL-22 in response to periodontopathic
bacteria is suspected and it is assumed to counteract with LPS of these bacteria and protect periodontal tissues against
adverse effects that results from stimulation of different cells and molecules of immune system by LPS.
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