Cytoglobin overexpression facilitates proliferation and migration of vascular smooth muscle cells
2020
Cytoglobin, a recently discovered globin, is expressed in vascular smooth
muscle cells (VSMCs). Loss of cytoglobin provides a protective effect on
vascular reconstruction but the effect of its overexpression is unclear. The
aim of the study was to investigate the effect of cytoglobin overexpression
on the migration and proliferation of VSMCs and possible mechanisms. We
detected the expression of cytoglobin in hypertensive and normotensive rat
aortas, with negative feedback regulation between cytoglobin and
hypertension observed. The expression of cytoglobin was significantly
decreased in hypertensive rats compared to normotensive rats, but VSMCs
overexpressing cytoglobin displayed increased cell migration and
proliferation, which led to a phenotypic switch. The increased expression of
matrix metalloproteinase 9 and collagen Ia suggests a role for cytoglobin in
extracellular matrix remodeling. Increased expression of proliferating cell
nuclear antigen and decreased expression of p27 implies that cytoglobin is
involved in modulating VSMC proliferation. Our findings indicate that
cytoglobin may play an important role in vascular wall remodeling.
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