Pharmacokinetics of intravenous pan-class I phosphatidylinositol 3-kinase (PI3K) inhibitor [14C]copanlisib (BAY 80-6946) in a mass balance study in healthy male volunteers

Michael Gerisch,Thomas Schwarz,Dieter Lang,Gabriele Rohde,Stefanie Reif,Isabelle Genvresse,Susanne Reschke,Dorina van der Mey,Camille Granvil

Pharmacokinetics of intravenous pan-class I phosphatidylinositol 3-kinase (PI3K) inhibitor [14C]copanlisib (BAY 80-6946) in a mass balance study in healthy male volunteers

2017

Michael Gerisch
Thomas Schwarz
Dieter Lang
Gabriele Rohde
Stefanie Reif
Isabelle Genvresse
Susanne Reschke
Dorina van der Mey
Camille Granvil

Purpose To determine the pharmacokinetics of radiolabeled copanlisib (BAY 80-6946) in healthy male volunteers and to investigate the disposition and biotransformation of copanlisib.

Keywords:

ADME
Phosphatidylinositol
Pharmacology
Disposition
Copanlisib
Pharmacokinetics
Kinase
Medicine
balance study
pharmacology toxicology
PI3K/AKT/mTOR pathway

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