INTERFERON α ANTIBODY AND USE OF THE SAME

PROBLEM TO BE SOLVED: To provide monoclonal antibodies capable of inhibiting surface expression of cell markers induced by IFNα, inhibiting IP-10 expression induced by IFNα, and inhibiting dendritic cell development mediated by plasma from patients with systemic lupus erythematosus. SOLUTION: The present invention provides anti-interferon α monoclonal antibodies, particularly human monoclonal antibodies, that inhibit the biological activity of multiple interferon (IFN) α subtypes but do not substantially inhibit the biological activity of IFNα21 or the biological activity of either IFNβ or IFNω. COPYRIGHT: (C)2011,JPO&INPIT