The Value of Thinprep Cytologic Test and High-risk HPV DNA Testing for Screening of Cervical Lesions

Objective To explore the value of thinprep cytologic test(TCT)and high-risk human papillomavirus DNA(HR-HPV DNA)detection in cervical disease screening.Methods 2876 cases of out-patients of cervical lesion patients from the gynecology department of the affiliated hospital of Yan′an University were given cervicitis TCT inspection,and patients with abnormal test results were further given HR-HPV DNA testing and pathological biopsy.Results 183 cases showed abnormal TCT results,including ASC-US 104 cases(56.83%),LSIL 48 cases(26.23%),HSIL 21 cases(11.48%),SCC 10 cases(5.46%).In 123 patients who were given HR-HPV DNA test,there were 87 cases(53.05%)showing HR-HPV DNA positive:ASC-US 29 cases(27.88%),LSIL 32 cases(66.67%),HSIL 17 cases(80.95%),SCC 9 cases(90.00%).Conclusion TCT is an accurate and convenient cellular method for cervical lesion screening,the combination with HR-HPV DNA test is an advanced approach to screen the cervical intraepithelial neoplasia and cervical cancer.