CAMK2A polymorphisms predict working memory performance in humans

Working memory is impaired in a number of psychiatric conditions.1, 2 An important role of alpha Ca2+/calmodulin dependent protein kinase II in learning and memory has been shown in rodent models. However, these findings have not been confirmed in humans yet. Here, we report genetic associations between the human CAMK2A gene and the performance in a spatial and a non-spatial working memory (non-SWM) task in two independent human samples.