The Incidence of Aneuploidy Significantly Increases After the Age of 40 in Women With a History of Recurrent Pregnancy Loss

rate, 68%, was significantly (p<0.001) higher than the cleavage stage pregnancy rate, 53%). There was no difference in the miscarriage rates between the clevage stage (11%) and the blastocyst stage (9%). Both cleavage and blastocsyt stage PGS yielded significantly (p<0.001) higher pregnancy rates than FISH PGS. Pregnancy rates decreased andmiscarriage rates increased in all groups with advancing maternal age. (Figure 1). CONCLUSION(S): PGS using 23 chromosome SNP microarrays in women with RPL was superior to FISH PGS and resulted in pregnancy rates of 58%. Furthermore, performing the biopsy at the blastocyt stagewas shown to be superior to cleavage stage biopsy. The application of dense microarray 23 chromosome PGS at the blastocyst stage may substantially improve pregnancy outcomes in couples suffering from RPL. SUPPORT: None.