Clinical Study on Infantile Congenital and Non-Congenital Cytomegalovirus Infection

Objective To learn the damage on infants and effect of treatment of congenital cytomegalovirus(CMV) infection and non-congenital cytomegalovirus infection which included perinatal infection and postnatal infection.Methods According to the diagnosis standard of cytomegalovirus infection in China,46 infants diagnosed CMV infection were retrospectively reviewed.In this research,CMV infection was diagnosed if serum CMV-IgM or CMV-pp65 in polymorphous leukocytes was positive.According to beginning time of CMV infection symptom,46 cases were divided into 2 groups: congenital infection and non-congenital infection,clinical features of 2 groups were compared.Ganciclovir was given to the infants with infantile hepatic syndrome of 2 groups,and compared liver transaminases and bilirulin with itself after treatment,side-effect was observed.Infants of 2 groups were followed up,and prognosis was compared.Results In 46 infants,21 were enrolled congenital infection group,25 were non-congenital infection group.CMV-IgM was positive in 38 cases of 46 patients,CMV-pp65 was positive in 19 cases of 43 patients,both CMVIgM and CMV-pp65 were positive in 11 cases.More congenital malformation were found in congenital group than non-congenital group,there was significant difference between 2 groups((P0.05).) Ganciclovir was given to 21 infants with infantile hepatic syndrome,after treatment,liver was withdrawed,liver transaminase and bilirulin decreased,side-effect of ganciclovir was found : neutropenia in 3 cases.Three infants in congenital infection group died during follow-up period, an infant in congenital infection group had abnormal auditory brain-stem evoked response(at 10 months.)More severe condition,more death,more congenital malformation had been found in congenital infection group than non-congenital infection group.Auditory damage had been found in congenital infection group and might be progressing after birth.Damage of liver and bile duct could exist,but prognosis of congenital infection group was not good.Conclusion The damage to infants is more severe in congenital group than that in non-congenital group.