O017 Beneficial Effects Of Renal Sympathetic Denervation On Pulmonary Vascular Remodeling And Right Ventricular Function In Experimental Pulmonary Artery Hypertension

Introduction: The sympathetic nervous system and renin-angiotensin-aldosterone system (RAAS) have been reported to be activated in pulmonary arterial hypertension (PAH). Hypothesis: This study tested the hypothesis that renal sympathetic denervation (RSD) decrease RAAS activity and inhibit pulmonary vascular remodeling in experimental PAH. Methods: Nineteen beagles were randomized into control (n=6), PAH (n=7) and PAH[[Unable to Display Character: ]]RSD (n=6) groups. Animals underwent percutaneous pulmonary artery catheterization to measure pulmonary hemodynamics before and 8 weeks after injection of 0.1 ml/kg dimethylformamide (Control dogs) or 2 mg/kg dehydromonocrotaline (PAH and PAH[[Unable to Display Character: ]]RSD dogs). The dogs in the PAH[[Unable to Display Character: ]]RSD group received double renal artery ablation before injection. Eight weeks after injection, levels of Angiotensin II (Ang II), pulmonary arterial tissue morphology and cardiac function were measured. Results: The levels of Ang...