Disturbances of brain maturation and neurodevelopment during chronic renal failure in infancy

Fifteen infants with moderate to severe congenital renal disease were prospectively studied by serial renal, neurodevelopmental, neurophysiologic, and anthropometric assessments. The observation period ranged from 3 to 25 months (mean=10.9). Eight patients maintained a Mental Development Index (MDI) above the 16th percentile (>−1 SD) and comprised group 1. Of the remaining seven patients (group 2), three had an MDI p p p p p