[Lys3]didemnins as potential affinity ligands

Abstract The synthesis and biological activity of N e -Z-[Lys 3 ]didemnin B are reported. This novel analogue retains antiproliferative, cytotoxic, and protein biosynthesis inhibition activities, but at reduced levels. This result suggests the use of [Lys 3 ]didemnin derivatives as potential affinity probes for studying the molecular target(s) of the didemnin class of natural products.