Nuclear Pore Complex Maturation is a Clock for Zygotic Genome Activation During Embryogenesis
2021
Highlights
● NPCs matures gradually in the zebrafish embryo after fertilization
● Maternal TFs cannot transport into nuclei efficiently in embryos before ZGA
● Nuclear pore complex maturity controls TFs nuclear transport and ZGA onset
● Dysfunction of nuclear pore complexes delays ZGA and embryonic development
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