Aziridine mediated asymmetric synthesis of α-benzylserine and α-n-butylserine
2001
Abstract Regioselective hydrogenolysis of enantiopure 2-benzyloxyaziridine 2-carboxylates represents a general method for the asymmetric synthesis of α-substituted serines. The aziridines are readily prepared via an aza-Darzens reaction of the enolate of methyl 3-benzyloxy-2-bromopropanoate with an enantiopure sulfinimine ( N -sulfinyl imine).
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