Design, Synthesis, and X-ray Crystallographic Studies of α-Aryl Substituted Fosmidomycin Analogues as Inhibitors of Mycobacterium tuberculosis 1-Deoxy-d-xylulose 5-Phosphate Reductoisomerase

Mounir Andaloussi,Lena M. Henriksson,Anna Wieckowska,Martin Lindh,Christofer Björkelid,Anna M. Larsson,Surisetti Suresh,Harini Iyer,Bachally R. Srinivasa,Terese Bergfors,Torsten Unge,Sherry L. Mowbray,Mats Larhed,T. Alwyn Jones,Anders Karlén

Design, Synthesis, and X-ray Crystallographic Studies of α-Aryl Substituted Fosmidomycin Analogues as Inhibitors of Mycobacterium tuberculosis 1-Deoxy-d-xylulose 5-Phosphate Reductoisomerase

2011

Mounir Andaloussi
Lena M. Henriksson
Anna Wieckowska
Martin Lindh
Christofer Björkelid
Anna M. Larsson
Surisetti Suresh
Harini Iyer
Bachally R. Srinivasa
Terese Bergfors
Torsten Unge
Sherry L. Mowbray
Mats Larhed
T. Alwyn Jones
Anders Karlén

The natural antibiotic fosmidomycin acts via inhibition of 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR), an essential enzyme in the non-mevalonate pathway of isoprenoid biosynthesis. Fosmi ...

Keywords:

Enzyme
Isoprenoid biosynthesis
Mycobacterium tuberculosis
1-deoxy-D-xylulose 5-phosphate reductoisomerase
Fosmidomycin
Aryl
Oxidoreductase
Biochemistry
Organic chemistry
Stereochemistry
Chemistry
Alpha (ethology)
design synthesis

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