Efficient Synthesis of Methyl6-(6-Aryl-1,2,4-triazin3-yl)pyridine-2-carboxylates
2020
Methyl 6-(6-aryl-1,2,4-triazin-3-yl)pyridine-2-carboxylates were synthesized
in up to 70% yield by one-step condensation of substituted ω-bromoacetophenones
with methyl 6-(hydrazinecarbonyl)pyridine-2-carboxylate in DMF. The reaction of
methyl 6-(hydrazinecarbonyl)pyridine-2-carboxylate with
2-bromo-1-[4-(methylsulfanyl)phenyl]ethan-1-one afforded exclusively the
corresponding arylglyoxal bishydrazone, dimethyl
6,6′-(2,2′-{1-[4-(methylsulfanyl)phenyl]ethane-1,2-diylidene}bis(hydrazine-1-carbonyl))bis(pyridine-2-carboxylate).
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