Trends in Pseudomonas aeruginosa Antibiotic Resistance: Case Study from a Portuguese Central Hospital

Aims: P. aeruginosa antibiotic resistance is increasing worldwide, greatly limiting therapeutic options, and is mainly associated to nosocomial infections, relating to high morbidity and mortality outcomes. Frequently updated regional guidelines, supported in statistically valid longitudinal information, are mandatory. Methodology: Resistance to 11 antibiotics used to treat P. aeruginosa infections were surveyed in clinical isolates from a Portuguese central during 10 years (n=3778) using the MicroScan WalkAway system. Statistical analysis (Mann-Whitney tests and regression modeling) were used to determine its time evolution according to origin, specimen samples and hospital wards. Data Article