Antioxydant and Antiplasmodial Activities of Extracts from Gardenia erubescence and Fadogia agrestis
2020
Two medicinal plants, Gardenia erubescens and Fadogia agrestis were selected to evaluate their biological
activities. Their total phenolic and flavonoid contents were assessed using folin-ciocalteu and aluminum
chloride regents’ methods. The antioxidant activity was estimated using DPPH
(1,1-diphenyl-2-picrylhydrazyl), ABTS (2,2’-azinobis-[3-ethylenzothiazoline-6-sulfonic
acid]) and FRAP (ferric reducing antioxidant
power). The antiplasmodial activity of the extracts was
determined in vivo on 42 NMRI mice. The results indicate that all the extracts
from both two plants contain some polyphenols. The ethanolic extract of the
leaves of Gardenia erubescens showed the best antioxidant
activity by the method of DPPH. The aqueous extracts of the leaves of Gardenia erubescens and the whole plant of Fadogia agrestis have a
reducing power similar to control (quercetin). All the extracts have a low
capacity to scavenge the ABTS radical cation compared to the controls (trolox
and quercetin). Concerning the antiplasmodial activity, all the extracts
presented moderate antiplamodial activities. This result could justify the
traditional uses of Gardenia erubescens and Fadogia agrestis to treat of malaria in Burkina Faso.
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