Immobilized Enzymes for Medical Application

The basic problems researchers deal with on the elaborattion of novel enzyme preparations are: increase of the enzyme stability in vivo realtive to the action of endogenous proteinases, inhibitors and antibodies; stability increase on storage; decrease of the organism response to foreign protein, and namely decrease of their immunogenicity, antigenicity, allergenicity potential and toxicity; decrease of the enzyme preparation dose; prolongation of the enzyme action or ensurance of the enzyme preparations pharmacokinetics.