Immobilized Enzymes for Medical Application
1980
The basic problems researchers deal with on the elaborattion of novel enzyme preparations are:
increase of the enzyme stability in vivo realtive to the action of endogenous proteinases, inhibitors and antibodies;
stability increase on storage;
decrease of the organism response to foreign protein, and namely decrease of their immunogenicity, antigenicity, allergenicity potential and toxicity;
decrease of the enzyme preparation dose;
prolongation of the enzyme action or ensurance of the enzyme preparations pharmacokinetics.
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