L-cell function and regulatory mechanism in obesity

Obesity is a high risk factor of diabetes.Several studies indicate that plasma glucagon like peptide(GLP) -1 and peptide YY (PYY) levels are decreased because of L-cell dysfunction in non-diabetic obese subjects.However,the mechanism of L-cell dysfunction in obesity is unclear.Abnormal concentrations and composition of plasma free fatty acids ( FFAs),leptin resistance,high level of plasma interleukin-6 (IL-6),aberrant composition and amount of gut microbiota may contribute to L-cell dysfunction.Exploring the mechanism of L-cell dysfunction is helpful to find new therapeutic targets for preventing the progression of obesity to diabetes. Key words: Obesity; L-cell; Glucagon-like peptide-1