Evaluation of long-term consumption of omeprazole disadvantages: a network analysis

Aim: Evaluation of deregulated genes after long-term consuming of omeprazole via network analysis. Background: Proton pump inhibitors (PPIs) are used to inhibit gastric high rate of acid secretion in patients. Omeprazole as a PPI is a common drug in this regard. Evaluation of long-term consumption of omeprazole is studied in the present study via its effects on the gene expression of “human coronary artery endothelial cells”. Methods: Net effect of the presence of omeprazole on gene expression profiles of “human coronary artery endothelial cells” was evaluated through data from gene expression omnibus (GEO). Results of protein-protein interaction (PPI) network analysis were assessed via biological process examination to find the critical deregulated genes after long-term consumption of omeprazole. Results: “Negative regulation of muscle cell apoptotic process”, “negative regulation of DNA binding”, “telencephalon cell migration”, “forebrain cell migration” “response to cadmium ion”, “cell-cell recognition”, “positive regulation of protein targeting to mitochondrion”, and “central nervous system neuron development” were the clusters of biological processes that were associated to the long -term presence of omeprazole. The final critical deregulated genes were JAK2, PTK2, and NRG1. Conclusion: It can be concluded that cell cycle, proliferation, and apoptosis and several essential biological processes are affected and nervous system is a possible target related to the long-term consumption of omeprazole. Keywords: Omeprazole, Long term consumption, Gene expression. (Please cite as: Nikzamir AR, Rezaei-Tavirani M, Razzaghi MR, Rezaei Tavirani S, Hamzeloo-Moghadam M, Esmaeili S, et al. Evaluation of long-term consumption of omeprazole disadvantages: a network analysis. Gastroenterol Hepatol Bed Bench 2020;13(Suppl.1):S98-S105).