Metallothionein and Malondialdehyde Correlation in Prostate Cancer Patients

Prostate cancer can be caused by heavy metals exposure that can be identified from increasing levels ofmetallothionein. Exposure to heavy metals is carcinogenic through the formation of ROS in the oxidativestress process. One of the markers of oxidative stress in prostate cancer is malondialdehyde. Purpose ofstudy to determine the relationship between levels of metallothionein and malondialdehyde in prostatecancer. Research design was cross sectional with subjects were 30 patients with prostate cancer at districthospital at Purwokerto, Indonesia. Measurement levels of metallothionein and malondialdehyde usedELISA sandwich method. Data analysis used Spearman correlation test. There was a correlation betweenlevels of metallothionein and malondialdehyde (p <0.05, r = 0.36). The increase of metallothionein levelcause enhancement malondialdehyde level. As a conclusion, study report that there was corelation betweenmetallothionein and malondialdehyde levels illustrates the process of oxidative stress on prostate cancer dueto heavy metals exposure.