Bronchodliator Effect of the Association Ipratropium Bromide plus Fenoterol (Low Doses) versus Terbutaline and Salbutamol in Bronchitic Patients

In 12 chronic bronchitic out-patients, during 3 successive days, the variations of FEV1 and Vmax25 were studied at 15, 30, 45,60, 120, and 180min after inhalation of: (1) [0.1 mg fenoterol (F) associated with 0.04 mg ipratropium bromide (IB)]; (2) [0.2 mg salbutamol (S)], and (3) [0.5 mg terbutaline (T)]. There were no secondary effects resulting from any treatment. Maximum effectiveness appeared on FEV1 at 60 min with F + IB, and at 45 min with S and T. On Vmax25, it was produced after 30 min with F + IB and no modifications in this parameter were observed either with S or with T. After 15 min, there were changes on FEV1 with the three products: P max25 increased since after 15 min (p