Vaccination in common variable immunodeficiency. A case

Abstract Objective In patients with primary immunodeficiencies (PI), vaccination can induce an adequate level of protection, similar to that of healthy individuals, which is why it is considered an effective tool for protection against serious infectious diseases. Common variable immunodeficiency (CVID) is a primary immunodeficiency, characterized by a defect in the antibody production. Materials and Methods Among the clinical manifestations of CVID, are recurrent and severe infections, autoimmunity failures, gastrointestinal manifestations, lymphoproliferative syndrome, and an increased risk of developing neoplasms. Infections are more frequent at the respiratory level. In this work, the case of a 19-year-old man diagnosed with CVID and its treatment by vaccination is presented. Results The patient's immune response after receiving the vaccines recommended as treatment is considered positive, with normal antibody levels, although maintaining low immunoglobulin G levels. Conclusions The administration of vaccines to patients with CVID can constitute a basic treatment tool for their disease.