Angiotensin II Type I Receptor Blockade is Associated with Decreased Cutaneous Scar Formation in a Rat Model

Background:Angiotensin II engagement of angiotensin II type 1 receptor (AT1R) is implicated in fibrogenesis, with AT1R blockers (ARB) used clinically to attenuate cardiac and renal fibrosis. The authors tested the hypothesis that the ARB losartan could reduce post-surgical cutaneous scarring in rats