Роль грамотрицательных бактерий в цитокиновом дисбалансе при пневмонии

The rat-experiments allowed identifying differences between the levels of systemic and local cytokines and dynamics of their production, depending on the aetiology of pneumonia. Enterobacter-induced pneumonia was characterized by increasing systemic production of g-interferon and interleukin-10. In case of pneumonia caused by Escherichia coli, the level of interferon did not change; the level of interleukin-10 in blood serum was considerably lower than that of intact animals. The local level of cytokines in case of pneumonia caused by Enterobacter spp. was characterised by activation of interleukin-10 and suppression in production of g-interferon measured two weeks after infection. The growing local prevalence of interleukin-10 concentration was observed in case of mice infected with E. coli. Therefore, Enterobacter spp. and E. mli have evident immune-depressive effects on pulmonary defence factors required to be taken into account when choosing methods of pathogenetic therapy of nosocomial pneumonia.