Determinants of Weight Gain in Women with Early-Stage Breast Cancer

Abstract : Weight gain after breast cancer diagnosis is common, and has been associated with poorer prognosis. The goals of the study are to examine weight gain relation to treatment-related changes in sex hormone levels, and in relation to genetic polymorphisms in sex hormone pathways, accounting for potential interactions with energy balance, psychosocial factors, tumor characteristics, cancer treatment, and medication use. A prospective longitudinal study of weight gain is being conducted in 215 stage I to IIIA breast cancer patients. During the first year of this grant, baseline and followup questionnaires were developed. Other recruitment materials developed included a consent script, a study brochure, instruction sheets, and data collection checklists. Study personnel were trained in consenting and recruitment of patients. Protocols for biospecimen collection were developed, which includes collection of serum, plasma, buffy coats, red blood cells, and overnight urine specimens. In collaboration with the departments of Clinical Research Services and the Information Technology, study databases were developed for tracking of patients, as well as for double entry of all data collected by survey. Participant recruitment using consent forms with DOD language began January 2007 after obtaining institutional IRB and USAMRMC Human Research Protections approval. Thirty seven participants have been enrolled using this consent form. The study will help identify women who are most susceptible to weight gain after being diagnosed with breast cancer, based on biologic characteristics as well as modifiable factors.